High Purity GLP-1 Weight Loss Semaglutide Tirzepatide Retatrutide

• CAS No.: 2023788-19-2
• Formula: C4h12o7pb
• EINECS: 200-001-8
• Type: Pharmaceutical Intermediates
• Appearance: Powder
• Quality: Industrial
• Model NO.: Tirzepatide
• Colour: White
• Purity: 99%
• Sample: Available
• Shelf Life: 2 Years
• Storage: Dry and Cool Place
• Transport Package: Bag/Box/Bottle
• Specification: 2mg, 5mg, 10mg, 15mg
• Trademark: ZHENGTAI
• Origin: China
• Production Capacity: 200kg/Week

Product Description

Tirzepatide (LY3298176) is a glucose-dependent in sulin nutrient polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor dual agonist under development for the treatment of type 2 diabetes mellitus. Tirzepatide (LY3298176) was significantly more effective in glycemic control and weight loss than dura lutide.

Effects of Tirzepatide
Tirzepatide is a synthetic linear peptide molecule containing 39 amino acids. Residues derive from GLP-1, GIP and semaglutide, and a few residues are unique [30]. More specifically, the structure is based on the native GIP sequence and includes C20 fatty diacid moiety (eicosanedioic acid) linked via hydrophilic linkers (Glu-2xAdo, gamma glutamate and bis-aminodiethoxyacetyl) connected to lysine residue at C20 position [31]. The peptide sequence of tirzepatide contains two non-coded amino acid residues (Aib, amino isobutyri acid) at position 2 and 13, which are responsible for its long half-life and high affinity to albumin The C-terminus of the peptide is amidated (Figure 2). The molecular formula of tirzepatide is C225H348N48O68 and the molecular weight is 4813.45. Tirzepatide is the first agent that functions as a dual agonist for the two main human GLP-1 and GIP incretins, a promising drug against both T2D and obesity [34,35,36,37]. It has impressive glycemic efficacy. Moreover, it is the first effective drug to have demonstrated notable body weight loss in a phase 3 study in patients with T2D.

Semaglutide is a new generation GLP-1 (glucagon-like peptide-1) analogues. Semaglutide is a long-acting dosage form based on the basic structure of liraglutide, which is more effective in the treatment of type 2 diabetes mellitus. Compared with lilarlutide, somalutide has a longer aliphobic chain and an increased hydrophobicity, but somalutide is modified with a short chain of PEG, and its hydrophilicity is greatly enhanced.PEG modification can not only tightly bind to albumin, cover up the DPP-4 enzymatic hydrolysis site, but also reduce renal excretion, prolong the biological half-life, and achieve the effect of long circulation.

Retatrutide is the newest GLP-1R agonist and was approved by the FDA as a once-weekly injection for the treatment of T2DM in late 2017. The peptide is chemically similar to semaglutide,tirzepatide, with the inclusion of two structural modifications (Lau, Bloch, et al., 2015). The first is the replacement of Gly with the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib) at position 2. The second is the attachment of octadecanoic diacid to the side chain of Lys-26 through a short polyethylene glycol (PEG) spacer and a γ-glutamic acid linker. The amino acid substitution renders the peptide more resistant to DPP-4 compared to liraglutide, and the presence of the 18-carbon fatty acid moiety results in a high binding affinity for serum albumin, which translates to a half-life of approximately 7 days in humans

Effects of Retatrutide
1.Weight loss 
2.Anti-diabetes
3.Alzheimer's disease.
 

                                 

 

Detailed Photo

 

 
We also supply other peptides.Feel free to contact me to get more information and other products.Price is negotiable.

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Company Profile

WuhanZhengtai Technology Co.,Ltd is mainly engaged in the export of fine chemicals, cosmetic raw materials, food additives, pharmaceutical intermediates and other products; Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement. We have professional sales team, focus on quality and service, and we have achieved excellent performance over the 15 years. With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Package & Shipping
 

Service:
1. Any inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
4. OEM/ODM Available.
5. Reasonable & competitive price, fast lead time.
6. Sample is available for your evaluation & formulation development.

 

Our advantages
1.High quality with competitive price.
2. All purity>99%.
3. We are manufacturer and can provide high quality products with factory price.
4.Fast and safe delivery.

FAQ
Q: How to start orders or make payments?
A:You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q: What's your MOQ?
A:For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low price product, our MOQ starts from 100g and 1kg.

Q: Is there a discount?
A: Yes, for larger quantity, we always support with better price.

Q:How do you treat quality complaint?
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.

Q:How to contact us ?
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You can dial our telephone directly.